Table 1

Integrity of the blood-cerebrospinal fluid barrier following nimesulide administration during experimental meningitis

Treatment Group (Intracisternal⁺ Drug)	Cerebrospinal Fluid White Blood Cell Infiltration (10⁶ cells/ml)	Cerebrospinal Fluid Evans Blue	Plasma Evans Blue
		μg/ml
Artificial cerebrospinal fluid ⁺ vehicle	None detected	0.22 ± 0.22	47.44 ± 3.36
Artificial cerebrospinal fluid ⁺ nimesulide	None detected	0.00 ± 0.00	54.79 ± 3.59
LPS ⁺vehicle	2.75 ± 0.93	11.58 ± 0.66^1-160	64.74 ± 5.76
LPS ⁺nimesulide	1.15 ± 0.25^1-165	10.58 ± 0.86^1-160	60.92 ± 6.13

↵1-160 p < 0.01 from all artificial cerebrospinal fluid groups by ANOVA with Newman-Keuls post hoc analysis.
↵1-165 p < 0.001 from LPS + vehicle by unpairedt test. n = 5–6 rats/treatment group.