Table 1

Hemodynamics, body weight, left and right ventricle-to-body weight ratio, and infarct size in sham-ligated rabbits, untreated MI rabbits, and MI rabbits treated with temocapril and valsartan

Sham LigationMIMI +TemocaprilMI + Valsartan
HR (beats/min)243  ± 7246  ± 12263  ± 10270  ± 8
SBP (mm Hg)117  ± 2104  ± 1** 103  ± 1** 106  ± 3**
DBP (mm Hg)68  ± 165  ± 162  ± 166  ± 2
MBP (mm Hg)87  ± 181  ± 278  ± 11-150 79  ± 21-150
BW (kg)2.32  ± 0.042.26  ± 0.092.26  ± 0.062.38  ± 0.04
LV/BW (g/kg)1.36  ± 0.031.72  ± 0.05** 1.40  ± 0.041-167 1.41  ± 0.051-167
RV/BW (g/kg)0.44  ± 0.020.67  ± 0.05** 0.45  ± 0.031-167 0.46  ± 0.021-167
IS (%)31  ± 428  ± 230  ± 4

The values are expressed as the means ± S.E. of five animals.

  • HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure; BW, body weight; LV, left ventricle; RV, right ventricle; IS, infarct size.

  • ↵1-150  P < 0.05, **P < 0.01 versus the respective sham ligation data.

  • ↵1-167 P < 0.01 versus the respective MI data.