Table 3

Cholinergic modulation of tetrodotoxin-sensitive GABAergic and glutamatergic transmissions in rat hippocampal slices

AgonistsResponsesPossible Receptors
NicotinicFacilitate spontaneous GABAergic transmission3-a α7, α4β2
Inhibit evoked GABAergic transmission3-b α7, α4β2
Facilitate spontaneous glutamatergic transmission3-c 3-d α7, α3β4
Inhibit evoked glutamatergic transmission3-c α7
MuscarinicInhibit GABAergic transmission3-e m2
Facilitate GABAergic transmission3-f m3
Inhibit glutamatergic transmission3-g m1

  • ↵3-a Alkondon et al., 1999;

  • ↵3-b Alkondon et al., 2000;

  • ↵3-c Radcliffe et al., 1999;

  • ↵3-d Alkondon and Albuquerque, 2002;

  • ↵3-e Pitler and Alger, 1992;

  • ↵3-f Martin and Alger, 1999;

  • ↵3-g Sheridan and Sutor, 1990.