Table 1

Soman has no significant effect on miniature IPSCs and EPSCs recorded from CA1 pyramidal neurons in rat hippocampal slices

Miniature IPSCsMiniature EPSCs
% control
Rise time1-a 105.8  ± 8.8796.1  ± 8.75
Decay-time constant1-b 98.5  ± 7.0797.7  ± 3.1
Peak amplitude95.8  ± 1.97102.2  ± 7.3
Frequency113.8  ± 10.3114.2  ± 11.7

The values of average rise time, decay-time constant, and peak amplitude and the frequency of events recorded from a given neuron for 3 min in the presence of 50 nM soman are represented as percentage of the values determined for events recorded from that neuron for 3 min under control conditions. Data are presented as mean ± S.E.M. of results obtained from four to six neurons, each from a different slice.

  • ↵1-a In the absence of soman, the rise time of miniature IPSCs and EPSCs was 6.0 ± 1.08 and 3.42 ± 0.98 ms, respectively.

  • ↵1-b In the absence of soman, the decay-time constant of miniature IPSCs and EPSCs was 47.0 ± 7.14 and 20.4 ± 5.74 ms, respectively.