Table 3

Mean ED₅₀ values and 95% CLs for the midazolam discrimination dose-effect curve alone and after pretreatment with various compounds

Drug/Dose	Midazolam Discrimination		Rate % Control ± S.E.M.
Drug/Dose	ED₅₀	95% CL	Before Midazolam	After Midazolam
	mg/kg
Control	0.15	0.08–0.23	102 ± 6	97 ± 4
⁺ Buspirone
0.1 mg/kg	0.13	0.03–0.33	96 ± 16	30 ± 15
0.32 mg/kg	0.09	0.01–0.22	102 ± 15	45 ± 36
1.0 mg/kg	N.S.	N.S.	36 ± 31	N.S.
⁺ GHB
100.0 mg/kg	0.22	0.05–0.51	87 ± 11	108 ± 12
320.0 mg/kg	0.22	0.05–0.49	91 ± 5	87 ± 27
560.0 mg/kg	0.03^3-a	0.01–0.07	105 ± 9	71 ± 12
⁺ Ketamine
1.0 mg/kg	0.12	0.10–0.13	109 ± 8	86 ± 25
3.2 mg/kg	N.S.	N.S.	0	N.S.
⁺ Diphenhydramine
3.2 mg/kg	0.14	0.06–0.25	145 ± 21	134 ± 19
10.0 mg/kg	0.09	0.08–0.10	132 ± 3	137 ± 25
17.8 mg/kg	0.34^3-a	0.20–0.54	129 ± 10	108 ± 35
⁺ Valproic acid
320.0 mg/kg	0.12	0.03–0.29	116 ± 11	110 ± 26
560.0 mg/kg	0.05^3-a	0.02–0.09	98 ± 17	83 ± 35
1000.0 mg/kg	0.03^3-a	0.01–0.08	96 ± 11	84 ± 56

Rate of responding includes rate after administration of the pretreatment drug alone (before midazolam) and rate after administration of the pretreatment drug followed by the dose of midazolam resulting in a group average of ≥80% midazolam-lever responding (after midazolam). Data are from at least three monkeys.

N.S., not studied.
↵3-a Significantly different from control (p < 0.05).