Drug/Dose | Flumazenil Discrimination | |
---|---|---|
ED50 | 95% CL | |
mg/kg | ||
Control | 0.03 | 0.01–0.06 |
Benzodiazepine site | ||
+ Flunitrazepam | ||
0.32 mg/kg | 0.092-a | 0.04–0.15 |
1.0 mg/kg | 0.212-a | 0.03–0.51 |
+ Abecarnil | ||
3.2 mg/kg | 0.082-a | 0.03–0.15 |
5.6 mg/kg | N.A. | N.A. |
Neuroactive steroid site | ||
+ Androsterone | ||
10.0 mg/kg | 0.072-a | 0.02–0.11 |
32.0 mg/kg | 0.332-a | 0.09–0.69 |
+ Dihydroandrosterone | ||
32.0 mg/kg | 0.122-a | 0.02–0.23 |
56.0 mg/kg | 0.302-a | 0.10–0.58 |
+ Epipregnanolone | ||
32.0 mg/kg | 0.072-a | 0.05–0.09 |
56.0 mg/kg | 0.092-a | 0.03–0.16 |
Data are from at least three monkeys.
N.A., not applicable; only one monkey responded ≥80% on the flumazenil lever.
↵2-a Significantly different from control (p < 0.05).