Species | Michaelis-Menten Kinetic Parameters for Acyl Glucuronidation of Diclofenac in Liver Microsomes | |||||
---|---|---|---|---|---|---|
Without Alamethicin | With Alamethicin | |||||
Vmax | Km | CL | Vmax | Km | CL | |
pmol/min/mg protein | μM | μl/min/mg protein | pmol/min/mg protein | μM | μl/min/mg protein | |
Rat | 606 | 14 | 43.3 | 4,160 | 20 | 208 |
Dog | 4,480 | 48 | 93.3 | 13,900 | 60 | 232 |
Human | 2,660 | 18 | 148 | 11,500 | 18 | 639 |