Effect of TAK-427 and dexamethasone on epidermal injury and eosinophil infiltration of the epidermis or crust in the OVA-induced eczema-like lesions of epicutaneously sensitized guinea pigs
| Drug | Dose | n | Epidermal Injury | Eosinophil Infiltration | ||
|---|---|---|---|---|---|---|
| Crust formation | Vacuolation | Epidermis | Crust | |||
| mg/kg, p.o. | ||||||
| Control | 11 | 2.7 ± 0.2 | 2.7 ± 0.2 | 2.2 ± 0.1 | 2.9 ± 0.3 | |
| TAK-427 | 0.3 | 12 | 2.5 ± 0.2 | 2.3 ± 0.1 | 1.8 ± 0.1 | 2.9 ± 0.3 |
| 3 | 12 | 2.3 ± 0.2 | 2.4 ± 0.3 | 1.8 ± 0.2 | 1.9 ± 0.3 | |
| 30 | 12 | 2.3 ± 0.1 | 2.1 ± 0.1 | 1.6 ± 0.13-150 | 1.7 ± 0.33-150 | |
| Control | 10 | 3.0 ± 0.3 | 3.0 ± 0.2 | 2.2 ± 0.1 | 2.4 ± 0.2 | |
| Dexamethasone | 1 | 10 | 2.6 ± 0.2 | 2.5 ± 0.2 | 2.1 ± 0.1 | 2.3 ± 0.2 |
| 3 | 10 | 2.9 ± 0.2 | 2.5 ± 0.2 | 2.1 ± 0.1 | 2.4 ± 0.2 | |
| 10 | 10 | 2.4 ± 0.2 | 2.1 ± 0.33-150 | 2.0 ± 0.0 | 2.3 ± 0.2 | |
OVA was applied with a patch to the shaved flank of epicutaneously sensitized guinea pigs. Drugs were administered p.o. twice daily for 3 days beginning the day before antigen challenge. Skin specimens were collected 48 h after antigen challenge. The histological preparations were scored on a scale of 1 to 4. Results are expressed as means ± S.E.M.
↵3-150 P < 0.05 vs. control (Dunnett's test).