Table 1

Summarized data of allodynia, gabapentin sensitivity, and calcium channel α2δ-1 subunit expression in neuropathic pain models

Neuropathic ModelsAllodyniaGabapentin Sensitivity↑ Calcium Channel α2δ-1 Subunit
DRGSpinal Cord
SNLYesYes +++ ++
SNTxYesYes ++
CCIYesYes +
DBYesYes +

Western blot data were obtained from tissue collected at time points when behavioral pharmacology data were collected as indicated in Fig.4. The number of plus signs in each column represents the relative degree of significant α2δ-1 subunit up-regulation compared within DRG or spinal cord samples only; Minus sign indicates no significant change.