Drug | Parameter | Value | CV Inter-Individual | 95% CI1-a | Unit | |
---|---|---|---|---|---|---|
1-PP Fixed | 1-PP | |||||
% | ||||||
Buspirone | CLB | 13.1 | 33 | 7.96–18.2 | ml/min | |
CLd,B | 41.7 | 35 | 23.9–59.4 | ml/min | ||
V 1,B | 8.94 | 96 | 4.92–12.9 | ml | ||
V 2,B | 626 | 38 | 467–785 | ml | ||
1-PP | CLB→1-PP | 4.53 | 51 | 1.63–7.43 | ml/min | |
CL1-PP | 8.22 | 31 | 35 | 6.51–9.89 | ml/min | |
CLd,1-PP | 123 | 35 | 24 | 84.2–162 | ml/min | |
V 1,1-PP | 8.32 | 131 | 213 | 2–14.6 | ml | |
V 2,1-PP | 924 | 66 | 34 | 722–1130 | ml | |
f B→1-PP | 25.7 | N.A. | N.A. | N.A. | N.A. | |
Buspirone CV intra-individual: 28% | ||||||
1-PP (metabolite) CV intra-individual: 51% | ||||||
1-PP (administered) CV intra-individual: 26% |
CV, coefficient of variation; N.A., not applicable.
↵1-a 95% CI is the 95% confidence interval over the precision of the estimated parameter.