Table 7

Correlation matrix of the interrelationship between drug affinities (pK_i values) at multiple classes of dopamine receptor, adrenoceptor, serotonin receptor, and at H₁ receptors

	h5-HT_1A	h5-HT_1B	h5-HT_1D	h5-HT_2A	h5-HT_2B	h5-HT_2C	hD₁	hD_2S	hD_2L	hD₃	hD₄	hD₅	hα_1A	hα_1B	hα_1D	rα_2D	hα_2A	hα_2B	hα_2C	H₁	hβ₁	hβ₂
h5-HT_1A	1.00
h5-HT_1B	0.85	1.00
h5-HT_1D	0.87	0.96	1.00
h5-HT_2A	0.90	0.89	0.92	1.00
h5-HT_2B	0.86	0.91	0.93	0.97	1.00
h5-HT_2C	0.76	0.86	0.79	0.87	0.83	1.00
hD₁	0.81	0.88	0.87	0.96	0.93	0.93	1.00
hD_2S	0.81	0.87	0.89	0.93	0.94	0.85	0.92	1.00
hD_2L	0.83	0.85	0.88	0.94	0.95	0.83	0.92	0.99	1.00
hD₃	0.63	0.73	0.79	0.78	0.72	0.76	0.76	0.80	0.80	1.00
hD₄	0.46	0.45	0.35	0.59	0.47	0.75	0.63	0.53	0.53	0.60	1.00
hD₅	0.68	0.79	0.78	0.88	0.86	0.91	0.91	0.84	0.84	0.72	0.63	1.00
hα_1A-AR	0.85	0.77	0.78	0.78	0.75	0.70	0.77	0.85	0.85	0.61	9.40	0.54	1.00
hα_1B-AR	0.83	0.77	0.82	0.81	0.77	0.67	0.75	0.85	0.83	0.62	0.35	0.59	0.93	0.94	1.00
hα_1D-AR	0.85	0.76	0.75	0.80	0.77	0.73	0.78	0.83	0.81	0.49	0.42	0.61	0.95	0.94	1.00
rα₂-AR	0.66	0.74	0.74	0.77	0.79	0.75	0.82	0.91	0.90	0.70	0.41	0.78	0.75	0.71	0.74	1.00
hα_2A-AR	0.77	0.82	0.79	0.80	0.80	0.79	0.84	0.87	0.88	0.64	0.38	0.78	0.81	0.74	0.81	0.95	1.00
hα_2B-AR	0.82	0.81	0.78	0.82	0.78	0.85	0.87	0.83	0.84	0.65	0.50	0.81	0.80	0.72	0.80	0.89	0.97	1.00
hα_2C-AR	0.74	0.71	0.70	0.77	0.76	0.78	0.79	0.84	0.86	0.60	0.42	0.79	0.76	0.71	0.78	0.93	0.95	0.93	1.00
H₁	0.57	0.56	0.52	0.57	0.49	0.64	0.54	0.59	0.62	0.77	0.66	0.50	0.52	0.40	0.36	0.54	0.52	0.58	0.55	1.00
hβ₁-AR	0.68	0.82	0.73	0.60	0.59	0.74	0.67	0.71	0.67	0.61	0.38	0.52	0.82	0.72	0.75	0.69	0.78	0.78	0.68	0.60	1.00
hβ₂-AR	0.69	0.79	0.69	0.64	0.61	0.77	0.74	0.73	0.71	0.65	0.50	0.55	0.82	0.66	0.73	0.74	0.81	0.84	0.71	0.68	0.95	1.00
	h5-HT_1A	h5-HT_1B	h5-HT_1D	h5-HT_2A	ht-HT_2B	h5-HT_2C	hD₁	hD_2S	hD_2L	hD₃	hD₄	hD₅	hα_1A	hα_1B	hα_1D	rα_2D	hα_2A	hα_2B	hα_2C	H₁	hβ₁	hβ₂

Values are Pearson product-moment correlation coefficients (r). All values were positive; values except those indicated in bold were not statistically significant.