Table 4

Affinities (pKi values) of antiparkinson agents at recombinant, human dopamine receptors

LigandhD1hD2ShD2LhD3hD4hD5
Apomorphine6.43 ± 0.057.46 ± 0.057.08 ± 0.017.59 ± 0.078.36 ± 0.077.83 ± 0.11
Bromocriptine6.16 ± 0.098.30 ± 0.087.83 ± 0.088.17 ± 0.046.43 ± 0.116.27 ± 0.05
Cabergoline6.67 ± 0.129.21 ± 0.069.02 ± 0.049.10 ± 0.047.25 ± 0.117.65 ± 0.08
Lisuride7.19 ± 0.099.47 ± 0.119.18 ± 0.049.55 ± 0.078.34 ± 0.074-a 8.45 ± 0.04
Pergolide6.47 ± 0.047.50 ± 0.117.59 ± 0.068.26 ± 0.117.23 ± 0.094-a 7.48 ± 0.21
Piribedil<56.88 ± 0.036.76 ± 0.076.63 ± 0.056.52 ± 0.10<5
Pramipexole<56.02 ± 0.025.77 ± 0.057.98 ± 0.056.89 ± 0.13<5
Quinelorane<56.50 ± 0.136.15 ± 0.048.27 ± 0.057.72 ± 0.164-a <5
Quinpirole<56.05 ± 0.055.84 ± 0.027.38 ± 0.077.47 ± 0.05<5
Ropinirole<56.17 ± 0.036.03 ± 0.067.43 ± 0.136.07 ± 0.064-a <5
Roxindole6.33 ± 0.138.55 ± 0.158.63 ± 0.108.93 ± 0.088.23 ± 0.066.72 ± 0.264-b
Talipexole<56.21 ± 0.026.01 ± 0.037.17 ± 0.036.48 ± 0.035.46 ± 0.11
Terguride7.55 ± 0.039.09 ± 0.118.94 ± 0.079.00 ± 0.068.09 ± 0.094-a 7.63 ± 0.05
TL995.57 ± 0.097.22 ± 0.107.17 ± 0.118.60 ± 0.137.24 ± 0.187.11 ± 0.08

Data are pKi values (minus log Kivalues) and, unless indicated, are expressed as means ± S.E.M. values of at least three independent determinations carried out in triplicate.

  • ↵4-a Mean ± range, n = 2.

  • ↵4-b Newman-Tancredi et al., 1997.