ED50 values for RWJ-51204 and eight GABA-based reference anxiolytics for increasing response rates in squirrel monkeys 1 h after p.o. administration
| Treatment | n6-a | Anxiolytic Efficacy | |
|---|---|---|---|
| Probit ED50 (95% FL) | Slope | ||
| RWJ-51204 | 4–17 | 0.49 (0.04–1.27) | 0.839 |
| Abecarnil | 5–6 | >10 | —6-b |
| Alprazolam | 6 | 0.06 (0.01–0.13) | 2.547 |
| Bretazenil | 4–6 | 0.02 (6-150–6-150) | —6-b |
| Clonazepam | 4–5 | 0.05 (6-150–6-150) | —6-b |
| Diazepam | 5–13 | 0.61 (0.20–1.13) | 2.775 |
| Imidazenil | 2–6 | 0.003 (6-150–6-150) | —6-b |
| Lorazepam | 5–27 | 0.06 (0.02–0.11) | 1.282 |
| Panadiplon | 4–6 | 0.05 (6-150–6-150) | —6-b |
↵6-150 95% Fiducial limits could not be determined, because the probit regression line deviated significantly from linearity.
↵6-a Number of observations/dose (up to 12 monkeys were used repeatedly).
↵6-b The slope of the probit regression line was not statistically significantly different from zero (P > 0.05).