Table 7

Effect of RWJ-51204 and eight GABA-based reference anxiolytics on the general behavior of squirrel monkeys 1 h after p.o. administration

(Dose for 100% Increase in Conflict Responding, mg/kg p.o.)^7-a	mg/kg p.o.	n^7-b	Locomotor Ataxia		Soft Body Tone		Decreased Agility		Slow Ambulation		Decreased Locomotor Activity
	mg/kg p.o.	n^7-b	Slight	Mod to Mk	Slight	Mod to Mk	Slight	Mod to Mk	Slight	Mod to Mk	Slight	Mod to Mk
RWJ-51204 (6.0)	0.1	4	0	0	0	0	1	0	1	0	0	0
	0.3	6	0	0	0	0	0	0	0	0	0	0
	1	6	0	0	0	0	0	0	0	0	0	0
	3	6	0	0	0	0	0	0	0	0	0	0
	10	6	2	0	0	1	1	0	1	2	0	0
	20	6	1	0	1	1	0	2	0	2	0	2
Abecarnil (>10)	0.01	6	0	0	0	0	0	0	0	0	0	0
	0.03	5	0	0	0	0	0	0	0	0	0	0
	0.1	6	0	0	0	0	0	0	0	0	0	0
	0.3	6	0	0	0	0	0	0	0	0	0	0
	1	6	0	0	0	0	0	0	0	0	0	0
	3	5	0	0	0	0	0	0	0	0	0	0
	10	5	0	0	0	0	0	0	0	0	0	0
Alprazolam (0.3)	0.03	6	0	0	0	0	0	0	1	0	0	0
	0.1	6	5	0	5	0	1	0	5	0	0	0
	0.3	6	0	6	0	6	0	6	0	6	0	0
	3	6	0	6	0	6	0	6	0	6	0	6
Bretazenil (1.0)	0.01	5	0	0	0	0	0	0	0	0	0	0
	0.03	5	0	0	2	0	0	0	2	0	0	0
	0.1	6	0	0	4	0	1	0	0	0	2	0
	0.3	6	0	0	0	0	0	0	2	0	0	0
	1	5	0	0	0	4	0	1	0	3	0	0
Clonazepam (0.1)	0.01	6	0	0	0	0	0	0	0	0	0	0
	0.03	6	0	0	0	0	0	0	0	0	0	0
	0.1	6	0	0	0	0	5	0	4	0	0	0
	0.3	6	1	0	3	1	5	1	0	5	0	1
	1	6	1	4	3	2	2	4	0	6	0	3
Diazepam (3.0)	0.3	6	0	0	0	0	1	0	2	0	0	0
	1	6	5	0	2	0	3	0	4	0	0	0
	3	12	4	6	2	8	2	8	2	10	0	2
	10	5	0	4	0	5	0	4	0	4	0	5
Imidazenil (0.03)	0.01	5	0	0	1	0	0	0	0	0	0	0
	0.03	4	0	0	1	0	0	0	0	1	0	0
	0.1	4	1	0	2	0	3	0	2	1	0	2
	0.3	6	0	0	2	2	2	0	4	0	0	0
	1	6	2	0	4	0	3	0	3	0	0	0
	3	6	0	2	0	5	0	5	0	6	0	0
Lorazepam (0.2)	0.03	6	0	0	0	0	0	0	0	0	0	0
	0.1	12	0	0	0	0	0	0	0	0	0	0
	0.3	12	0	0	0	0	0	0	0	0	0	0
	1	10	1	2	0	1	0	5	0	5	0	0
	3	9	1	5	1	4	1	6	1	6	0	5
	10	6	1	5	1	5	1	5	1	5	0	4
Panadiplon (3.0)	0.03	4	0	0	0	0	0	0	0	0	0	0
	0.1	4	0	0	0	0	0	0	0	0	0	0
	0.3	5	0	0	1	0	0	0	0	0	0	0
	1	5	0	0	1	0	0	0	0	0	0	0
	3	6	0	0	0	0	0	0	0	0	0	0

↵7-a Dose for 100% increase in conflict responding was taken from the linear regression of the dose-response lines.
↵7-b Five behavioral and physical signs were routinely and closely monitored and documented in the monkeys that received each dose of drug in the conflict experiments.