Influence of flumazenil on the suppression of anxiety by RWJ-51204 and lorazepam in the Vogel test in rats
| Treatment | mg/kg p.o. | n | Median Shocks (Middle 50% Range) | P4-a | P4-b |
|---|---|---|---|---|---|
| Vehicle and PEG | 0 | 8 | 7.5 (3.0–11.5) | ||
| RWJ-51204 and PEG | 0.1 | 8 | 4.0 (3.0–6.0) | 0.15 | |
| RWJ-51204 and PEG | 1 | 8 | 17.0 (8.0–22.0) | 0.05 | |
| RWJ-51204 and PEG | 10 | 8 | 33.5 (20.5–37.5) | <0.01 | |
| RWJ-51204 and PEG | 100 | 8 | 27.0 (21.5–36.5) | <0.01 | |
| Vehicle and flumazenil (10) | 0 | 8 | 3.5 (3.0–5.0) | ||
| RWJ-51204 and flumazenil (10) | 0.1 | 8 | 3.0 (3.0–5.0) | 0.37 | 0.31 |
| RWJ-51204 and flumazenil (10) | 1 | 8 | 6.5 (4.0–15.0) | 0.06 | 0.07 |
| RWJ-51204 and flumazenil (10) | 10 | 8 | 5.0 (2.5–24.5) | 0.24 | 0.01 |
| RWJ-51204 and flumazenil (10) | 100 | 8 | 17.5 (13.0–27.0) | <0.01 | <0.05 |
| Lorazepam and PEG | 2 | 8 | 18.0 (11.0–23.5) | <0.05 | |
| Lorazepam and flumazenil (10) | 2 | 8 | 5.0 (5.0–8.5) | 0.09 | 0.01 |
↵4-a Probability that the median number of shocks (Dunn's test, two-tailed) in the test group is not greater than the response in the corresponding vehicle-treated group.
↵4-b Probability that the median number of shocks (Dunn's test, two-tailed) in groups that received flumazenil is not less than the response in the corresponding vehicle-treated group.