Potencies (ED50 values) of RWJ-51204 and seven GABA-based reference anxiolytics in conflict-induced anxiety (Vogel test) sedative activity in the horizontal motor activity test in rats
| Treatment (1 h after Administration) | Anxiolytic Activity | Sedative Activity | ||
|---|---|---|---|---|
| n3-a | Vogel Conflict ED50 95% FL | n3-a | Horizontal Locomotion ED50, 95% FL | |
| mg/kg p.o. | mg/kg p.o. | |||
| RWJ-51204 | 127 | 0.4 (0.1–0.9) | 149 | 0.3 (0.1–1.0) |
| Abecarnil | 47 | 1.3 (0.5–2.3) | 28 | 0.8 (0.3–2.0) |
| Bretazenil | 90 | 0.6 (0.0–2.2) | 41 | >3.0 |
| Clonazepam | 32 | 2.6 (1.4–4.6) | 24 | >10.0 |
| Diazepam | 24 | 5.8 (4.2–8.1) | 45 | >10.0 |
| Imidazenil | 45 | 1.0 (0.5–2.0) | 38 | >30.0 |
| Lorazepam | 176 | 0.6 (0.3–0.8) | 250 | 0.4 (0.3–0.6) |
| Panadiplon | 32 | 2.4 (0.9–10.4) | 30 | >30.0 |
↵3-a Number of rats used in the calculation of the respective ED50 values. Anxiolytic and sedative activities in the elevated plus maze were determined from data obtained from the same rats.