Table 2

Mean ± S.E.M. ratings on the VAS after buprenorphine or buprenorphine/naloxone administration

Placebo2 mg of BUP8 mg of BUP2 mg of BUP/NX8 mg of BUP/NX
Like0.98  ± 0.227.31  ± 2.3521.56  ± 4.762-a 3.25  ± 0.845.60  ± 1.86
Potent0.83  ± 0.215.38  ± 1.8819.27  ± 4.382-a 2.98  ± 0.816.31  ± 2.01
Would pay0.19  ± 0.010.50  ± 0.172-b 3.06  ± 0.722-a 0.75  ± 0.240.67  ± 0.252-c

  • ↵2-a  Significant difference from placebo.

  • ↵2-b  Significant difference between 2 and 8 mg of buprenorphine or between 2 and 8 mg of the combination.

  • ↵2-c  Significant difference between buprenorphine alone and the combination at that dose (P < 0.01).