Table 1

Effects of repeated cocaine treatment on the levels of brain mGluR2/3 proteins by immunoblotting

Brain RegionmGluR2/3Saline RatsCocaine Rats
Prefrontal cortexDimer100  ± 22.6166.7  ± 21.31-150
Monomer100  ± 5.755.9  ± 9.71-150
Dimer + monomer100  ± 12.5125.6  ± 15.9
Pariatal cortexDimer99.99  ± 9.896.2  ± 11.3
MonomerN.D.N.D.
StriatumDimer100  ± 11.1113.7  ± 8.3
Monomer100  ± 8.9101.0  ± 10.6
Dimer + monomer100  ± 9.9110.8  ± 7.9
Accumbens, shellDimer100  ± 8.2130.9  ± 6.71-150
Monomer100  ± 12.485.3  ± 5.9
Dimer + monomer100  ± 9.5124.8  ± 5.61-150
Accumbens, coreDimer100  ± 7.3132.8  ± 10.11-150
Monomer100  ± 6.5103.2  ± 14.5
Dimer +monomer100  ± 5.8121.3  ± 7.61-150
VTADimer100  ± 14.8126.4  ± 7.9
Monomer100  ± 13.5108.4  ± 12.3
Dimer +monomer100  ± 14.4119.5  ± 6.2

Rats were killed at 3 weeks after the last daily cocaine injection. Data are shown as the normalized percentage of change (mean ± S.E.M.) from rats pretreated with daily saline injections.n = 7 for each group and brain area.

  • N.D., not detected; VTA, ventral tegmental area.

  • 1-150p < 0.05, compared with the saline control group with two-tailed Student's t test.