Dose (μg/kg) | HR | SBP | DBP | LVP | LVEDP | +dP/dtmax |
---|---|---|---|---|---|---|
bpm | mm Hg | mm Hg/s | ||||
PST2744 (300) | ||||||
Before | 129 ± 5.7 | 122 ± 3.8 | 93 ± 6.0 | 125 ± 2.6 | 6.6 ± 1.9 | 4963 ± 341 |
After | 135 ± 5.8 | 138 ± 6.73-150 | 90 ± 5.1 | 148 ± 4.13-160 | 7.4 ± 0.8 | 7710 ± 5103-160 |
Digoxin (75) | ||||||
Before | 127 ± 11 | 128 ± 10 | 104 ± 7.5 | 133 ± 8.6 | 8.1 ± 2.3 | 4969 ± 604 |
After | 94 ± 7.23-150 | 136 ± 7.8 | 109 ± 8.2 | 136 ± 9.4 | 5.1 ± 1.9 | 4780 ± 344 |
Vehicle | ||||||
Before | 128 ± 8.8 | 127 ± 3.4 | 98 ± 2.4 | 127 ± 3.2 | 6.7 ± 1.8 | 5070 ± 466 |
After | 127 ± 5.3 | 128 ± 4.4 | 98 ± 2.2 | 128 ± 3.9 | 6.7 ± 2.2 | 4928 ± 479 |