Table 2

Agonist potencies of NPY and NPY analogs acting at the various rat NPY receptor subtypes

Agonist	EC₅₀Value		Selectivity	Reference
Agonist	Y₁	Y₂	Y₄	Reference	Y₅	Y₁:Y₂:Y₄:Y₅
	nM
NPY	0.35	2.1	279	1.6	1:6:797:4.6	Hwa et al., 1999
[Leu³¹Pro³⁴]-NPY	2.69	261	3.8	?^2-a	1:97:1.4:≤1	Balsubramaniam et al., 2000
PYY_3–36	193	1.4	518	8.8	138:1:370:6.3	Hwa et al., 1999
[d-Trp³⁴]-NPY	363	3715	525	15	24.2:248:35:1	Parker et al., 2000
WX-143B	79.4	530	2	280	39.7:265:1:140	A. Balasubramaniam, personal communication

↵2-a Agonist potency data not available; binding data indicate affinity values ≤1 nM (Blomqvist and Herzog, 1997).