Percentage amino acid identity of bH1 versus four sodium channel isoforms
Isoform
N
DI
L1
DII
L2
DIII
L3
DIV
C
Nav1.5 (rH1)
92
95
86
97
80
97
100
98
93
Nav1.5 (hH1)
92
95
86
95
81
97
100
96
92
Nav1.2 (α2)
56
72
38
77
46
71
90
77
63
Nav1.4 (μ1)
58
67
41
80
29
80
86
80
71
rH1, rat heart (Swissprot P15389); hH1, human heart (SwissprotQ14524); α2, rat brain 2 (Swissprot P04775); μl, rat skeletal muscle (Swissprot P15390). N, amino terminus; DI to DIV, domains one to four; C, carboxy terminus; L1 to L3, intracellular loops linking the four domains.