Table 2

Effects of A-278637, WAY-133537, ZD6169, and nifedipine on unstable bladder contractions and cardiovascular parameters in obstructed pigs

Compound	Dose	n	Suppression of Unstable Contractions		Cardiovascular Parameters
Compound	Dose	n	Total AUC/30 min	AUC/Contraction	Frequency	Amplitude	Duration	Mean Arterial Pressure	Heart Rate
	nmol/kg i.v.
Vehicle	Period 1	4	5 ± 8	8 ± 5	−6 ± 5	4 ± 7	−3 ± 9	2 ± 2	−2 ± 5
	Period 2	4	−1 ± 7	7 ± 1	1 ± 10	2 ± 9	5 ± 3	3 ± 3	−5 ± 4
A-278637	3	4	−26 ± 6^2-150	6 ± 2	−31 ± 5	7 ± 4	−2 ± 4	0 ± 4	−5 ± 2
	10	4	−51 ± 4^2-150	−23 ± 5	−35 ± 6	−25 ± 10	−4 ± 7	−7 ± 8	−3 ± 6
	30	4	−75 ± 11^2-150	−32 ± 18	−68 ± 10	−31 ± 18	−3 ± 5	−29 ± 4^2-150	−11 ± 4
WAY-133537	30	3	−14 ± 9	−1 ± 9	−13 ± 3	1 ± 4	1 ± 4	−4 ± 3	−4 ± 3
	100	3	−28 ± 10^2-150	−11 ± 10	−20 ± 4	−7 ± 11	−2 ± 3	−20 ± 3^2-150	−13 ± 7
	300	3	−90 ± 3^2-150	−30 ± 9	−86 ± 6	−28 ± 7	−6 ± 7	−38 ± 3^2-150	12 ± 4
ZD6169	100	3	−1 ± 4	−1 ± 11	5 ± 16	2 ± 4	−3 ± 12	−2 ± 6	3 ± 8
	300	4	−25 ± 4^2-150	−18 ± 3	−8 ± 6	−14 ± 4	2 ± 9	−4 ± 2	−14 ± 3
	1000	4	−46 ± 13^2-150	−20 ± 7	−33 ± 12	−16 ± 7	−12 ± 4	−21 ± 4^2-150	−8 ± 3
Nifedipine	30	4	9 ± 10	−2 ± 5	11 ± 9	−6 ± 5	4 ± 4	−10 ± 3	8 ± 4
	100	5	−24 ± 9^2-150	−32 ± 8	9 ± 10	−26 ± 7	−12 ± 4	−29 ± 4^2-150	13 ± 4^2-150

Data expressed as mean ± S.E.M. percentage of change from predose control values shown in Table 1.

↵2-150 p ≤ 0.05 ANOVA followed by Newman-Keuls multiple comparison; analysis applied only to AUC and MAP data because those parameters were the ones used to compare compounds.n, Number of animals tested.