In vitro analysis of tissue selectivity
| Compound | Bladder Spontaneous Phasic Activity | Thoracic Aorta 25 mM K+-Evoked Contractions | Portal Vein Spontaneous Phasic Activity |
|---|---|---|---|
| −log IC50 | |||
| A-278637 | 7.64 ± 0.06 | 7.34 ± 0.07 | 7.74 ± 0.39 |
| WAY-133537 | 6.99 ± 0.06 | 7.36 ± 0.07 | 7.30 ± 0.08 |
| ZD6169 | 6.68 ± 0.11 | 7.49 ± 0.27 | 7.47 ± 0.22 |
Number of experiments was three to six each carried out in duplicate.