Table 7

Activity of hepatic enzymes of guinea pigs treated with 0, 0.8, 3.7, and 13.4 mg/kg/day ASBT inhibitor

TreatmentACATCPY7
mg/kg/day pmol/min/mg pmol/h/mg
ASBT inhibitor
  047.4 ± 14.87-a 22.8 ± 6.0
  0.839.6 ± 9.07-b 24.1 ± 8.0
  3.737.6 ± 9.57-b 19.9 ± 5.5
 13.433.4 ± 8.17-150 32.6 ± 8.87-150

Data are presented as means ± S.D.: N = 10 group. Values in the same column with different superscripts are significantly different as determined by one-way ANOVA and the Newman-Keuls as post hoc test.

  • 7-150P < 0.05.

  • 7-a Control.

  • 7-b Trend toward dose-dependent response. Not significant.