Table 1

Effect of azithromycin, clarithromycin, erythromycin, and the combination of erythromycin and azithromycin on QT-interval, MAP duration, and dispersion of refractoriness

Cycle LengthQT-IntervalMean APD50Disp APD50Mean APD90Disp APD90
μM
AzithromycinBaseline234  ± 19113  ± 1636  ± 17162  ± 1527  ± 8
150300  ± 31181  ± 3056  ± 22219  ± 2644  ± 21
200311  ± 31186  ± 3775  ± 22229  ± 2950  ± 18
300338  ± 42180  ± 32103  ± 17223  ± 2786  ± 26
ClarithromycinBaseline244  ± 24141  ± 1454  ± 20175  ± 1649  ± 22
150270  ± 25156  ± 2650  ± 17204  ± 2539  ± 20
200283  ± 25144  ± 1858  ± 29200  ± 2352  ± 19
300306  ± 26156  ± 3281  ± 38227  ± 3981  ± 52
ErythromycinBaseline226  ± 23124  ± 1837  ± 20159  ± 1537  ± 24
150243  ± 28136  ± 2053  ± 18176  ± 1646  ± 23
200258  ± 25143  ± 2156  ± 17189  ± 2348  ± 16
300290  ± 49153  ± 2175  ± 31203  ± 2463  ± 30
Erythromycin +azrthromycinBaseline233  ± 28128  ± 1946  ± 22165  ± 2140  ± 27
300259  ± 52140  ± 2266  ± 28190  ± 2358  ± 31
300 + 150339  ± 79180  ± 5698  ± 51259  ± 4879  ± 37

Data in milliseconds.

  • Disp, dispersion.