In vitro effects of bile acids on transporter expression in Hepa1-6 cells
| mRNA Levels (% Control) | ||||
|---|---|---|---|---|
| Mrp1 | Mrp2 | |||
| 6 h | 24 h | 6 h | 24 h | |
| Control | 100 ± 9 | 100 ± 13 | 100 ± 6 | 100 ± 14 |
| Taurocholate 25 μM | 117 ± 4 | 90 ± 10 | 101 ± 7 | 74 ± 7 |
| Taurocholate 100 μM | 110 ± 21 | 85 ± 14 | 106 ± 15 | 84 ± 10 |
| Cholic Acid 25 μM | 50 ± 92-150 | 143 ± 13 | 107 ± 15 | 108 ± 6 |
| Cholic Acid 100 μM | 44 ± 92-150 | 161 ± 122-150 | 91 ± 16 | 124 ± 4 |
Values are expressed as mean ± S,E,M. (n = 4).
↵2-150 p < 0.05.