Baseline clinical and biochemical characteristics in patients with CAD (n = 27)
| Parameter | All (n = 27) | tHcy Reduction above Median (n = 14) | tHcy Reduction below Median (n = 13) | P |
|---|---|---|---|---|
| Age, yr (range) | 50.3 ± 6.2 | 48.5 ± 6.5 | 52.1 ± 5.5 | N.S. |
| Body mass index, kg/m2 | 27.0 ± 2.9 | 26.5 ± 3.5 | 27.4 ± 2.1 | N.S. |
| Smoking | ||||
| Never | 12 (44.4%) | 6 (42.8%) | 6 (46.1%) | N.S. |
| Former | 15 (55.5%) | 8 (57.1%) | 7 (53.8%) | N.S. |
| Current | ||||
| Arterial hypertension | 14 (51.8%) | 6 (42.8%) | 8 (61.5%) | N.S. |
| TAS, mM | 0.918 ± 0.028 | 0.912 ± 0.037 | 0.923 ± 0.045 | N.S. |
| Plasma homocyst(e)ine, μM | 12.2 ± 0.8 | 14.4 ± 1.1 | 9.7 ± 0.7 | 0.002 |
| Plasma folate, ng/ml | 6.7 ± 0.8 | 5.1 ± 0.6 | 8.5 ± 1.4 | 0.03 |
| Plasma vitamin B12, ng/l | 377 ± 26 | 377 ± 37 | 377 ± 35 | N.S. |
| Serum vitamin B6, ng/l | 16.8 ± 4.5 | 18.8 ± 7.1 | 13.7 ± 3.7 | N.S. |
| Plasma cholesterol, mM | 205 ± 9 | 223 ± 13 | 184 ± 8 | 0.03 |
| Plasma triglycerides, mM | 161 ± 25 | 171 ± 47 | 150 ± 11 | N.S. |
| Lipoprotein(a), mM | 21.4 ± 3.8 | 17.4 ± 4.7 | 24.8 ± 5.8 | N.S. |
Data are mean ± S.E. and percentage of a group. Pvalue compares reponders to nonresponders.
N.S., not significant.