Table 1

Effect of GSH depletion on MAQ-NOH-induced TBARS formation

TreatmentTBARS
μM
Control0.15  ± 0.18
MAQ-NOH0.35  ± 0.111-a
MAQ-NOH (−GSH)1-b 0.25  ± 0.151-a

Rat erythrocyte suspensions (2 ml, 40% hematocrit in PBSG) were incubated at 37°C for 60 min with the vehicle (20 μl of DMSO) or MAQ-NOH (250 μM). The values shown are means ± S.D. (n = 3).

  • ↵1-a  Significantly different from the control (p < 0.05).

  • ↵1-b  Red cell GSH was depleted by >90% of normal levels using DEM pretreatment as described underMaterials and Methods..