Table 4

Effect of BMS-191095 on ventricular refractory period (VERP, milliseconds), conduction time (VCT, milliseconds), conduction velocity (VCV, millimeters per second), wavelength, and monophasic APDs at 90% repolarization (APD90, milliseconds)

Dose	VERP		VCT		VCV		Wavelength
Dose	Absolute	% Δ	Absolute	% Δ	Absolute	% Δ	Absolute
mg/kg i.v.
BCL 400 ms
0.0	150 ± 1		53 ± 2		38 ± 1		57 ± 2
0.3	150 ± 1	0 ± 0	52 ± 2	−2 ± 2	39 ± 1	2 ± 2	58 ± 2
1.0	149 ± 1	−1 ± 1	52 ± 2	−2 ± 2	39 ± 2	2 ± 3	58 ± 2
3.0	148 ± 1	−1 ± 1	52 ± 2	−1 ± 2	39 ± 1	1 ± 2	57 ± 2
10.0	150 ± 1	0 ± 1	52 ± 2	−1 ± 2	38 ± 1	1 ± 2	57 ± 2
BCL 333 ms
0.0	140 ± 1		51 ± 2		39 ± 1		55 ± 1
0.3	139 ± 1	0 ± 1	51 ± 2	0 ± 1	39 ± 1	1 ± 1	55 ± 2
1.0	140 ± 1	1 ± 1	51 ± 2	−1 ± 1	40 ± 2	1 ± 2	55 ± 2
3.0	141 ± 1	1 ± 0	51 ± 2	−1 ± 2	40 ± 2	2 ± 2	56 ± 2
10.0	139 ± 1	−1 ± 0	52 ± 2	1 ± 2	39 ± 1	0 ± 2	54 ± 2
BCL 286 ms
0.0	130 ± 1		52 ± 2		38 ± 1		50 ± 1
0.3	132 ± 1	2 ± 0	51 ± 2	−2 ± 1	39 ± 1	2 ± 1	52 ± 2
1.0	133 ± 1	2 ± 1	51 ± 2	−3 ± 1	40 ± 2	3 ± 2	53 ± 2
3.0	131 ± 1	1 ± 1	51 ± 2	−3 ± 2	40 ± 2	3 ± 2	52 ± 2
10.0	132 ± 1	2 ± 1	52 ± 2	−2 ± 1	39 ± 1	2 ± 1	52 ± 2