Table 4

Effects of various store-operated Ca²⁺ entry blocker on Mn²⁺ entry induced by PACAP and thapsigargin (TG) in adrenal chromaffin cells

Addition	PACAP-Induced Mn²⁺Entry		TG-Induced Mn²⁺ Entry
Addition	1 min after	5 min after	1 min after	5 min after
	% control		% control
10 μM SK&F 96365	1.44 ± 5.23^4-150	16.61 ± 6.84^4-150	−5.31 ± 8.52^4-150	0.57 ± 8.78^4-150
5 μM LOE 908	12.79 ± 5.39^4-150	19.90 ± 11.44^4-150	8.68 ± 7.09^4-150	4.30 ± 13.80^4-150
5 μM Econazole	6.89 ± 3.20^4-150	14.48 ± 4.95^4-150	1.01 ± 5.39^4-150	−0.94 ± 9.10^4-150
30 μM 7,8-Benzoflavone	87.93 ± 2.79	83.60 ± 7.90	5.21 ± 2.78^4-150	8.65 ± 6.73^4-150
100 μM NDGA	80.13 ± 8.88	106.43 ± 12.62	3.91 ± 6.47^4-150	6.78 ± 7.45^4-150
100 μM NPPB	70.12 ± 3.92	98.33 ± 7.11	−16.75 ± 4.46^4-150	16.34 ± 7.02^4-150
100 μM Fulfenamic acid	93.43 ± 9.85	83.65 ± 3.33	10.19 ± 12.34^4-150	10.86 ± 14.20^4-150
0.5 mM Niflumic acid	111.30 ± 1.92	135.05 ± 5.12	35.81 ± 12.41^4-150	27.86 ± 14.22^4-150

Values represent percentage of control calculated as described in Table3, except that Mn²⁺ entry induced by PACAP and TG at 1 and 5 min were 25.54 ± 1.64 and 23.61 ± 1.53 for PACAP and 14.89 ± 0.78 and 16.58 ± 1.52 for TG, respectively, and the basal Mn²⁺ entry in the presence of drugs tested (basal values at 1 and 5 min were 25.44 ± 1.05 and 55.11 ± 0.96; SK&F 96365, 14.70 ± 1.85 and 38.08 ± 4.48; LOE 908, 15.98 ± 0.73 and 46.55 ± 3.16; econazole, 16.51 ± 1.22 and 45.55 ± 3.16; 7,8-benzoflavone, 25.45 ± 4.24 and 57.10 ± 4.47; NDGA, 19.95 ± 1.45 and 46.48 ± 0.62; NPPB, 20.87 ± 2.83 and 46.66 ± 3.50; fulfenamic acid, 25.08 ± 2.86 and 54.27 ± 2.70; niflumic acid, 13.37 ± 2.63 and 37.50 ± 4.23, respectively).

↵4-150 Significantly different from the corresponding control at p < 0.01.