Table 2

Severity of inflammation scores

DoseTotal ScoreStomachCecum
i.p. study
 Saline13.25  ± 0.712.8  ± 0.325.85  ± 0.36
 Antisense control13.20  ± 0.82  ± 0.635.6  ± 0.4
 0.5 mg/kg9.3  ± 0.62cd 1.9  ± 0.324.65  ± 0.272-a
 1 mg/kg9.85  ± 0.5cd 1.85  ± 0.464.6  ± 0.232-a
 5 mg/kg10.68  ± 0.51cd 2.22  ± 0.254.72  ± 0.422-a
Rectal study
 Antisense control15.4  ± 0.43.4  ± 0.246.1  ± 0.24
 0.5 mg/kg13  ± 0.172-d 3  ± 0.015.2  ± 0.222-b
 1 mg/kg11.8  ± 0.282-d 2.2  ± 0.162-d 5.4  ± 0.22-b
 5 mg/kg12.9  ± 0.332-d 3.4  ± 0.165.5  ± 0.17
  • 2-a  p ≤ 0.05 (using saline placebo).

  • 2-b p ≤ 0.05 (using mixed antisense placebo).

  • 2-c p ≤ 0.001 (using saline placebo).

  • 2-d p ≤ 0.001 (using mixed antisense placebo).