Table 4

Morphological recovery of the damaged sciatic nerve on treatment with 13-Me-18-OH FK520 at 0 (vehicle alone), 1, and 5 mg/kg/day at day 18 postinjury

Mean Axonal Area (Myelinated and Unmyelinated)Mean No. of Axons
Total AxonsLargest 30%UnmyelinatedMyelinated
μM
Vehicle alone1.46  ± 0.083.11  ± 0.1886  ± 1911  ± 4
Veh + 1 mg/kg1.93  ± 0.064-150 4.01  ± 0.124-150 71  ± 1612  ± 4
Veh + 5 mg/kg2.29  ± 0.084-160 4.74  ± 0.154-160 104  ± 2022  ± 44-150
Undamaged nerve3.02  ± 0.198.82  ± 0.3792  ± 358  ± 3

For comparison, the values for undamaged soleus nerve are also given. The values are ± S.E.M.

  • Veh, vehicle.

  • ↵4-150  Values that are greater than the vehicle alone control group at the 0.05 significance level.

  • ↵4-160  Values that are greater than the 1 mg/kg/day group at the 0.05 significance level.