Pharmacokinetic parameters for VX-148 following its oral administration to male and female CD-1 mice n = 3/sex/group
| Dose Sex | AUC0–t | AUC0–∞ | T1/2 | Cmax | Tmax |
|---|---|---|---|---|---|
| mg/kg | μg × h/ml | h | μg/ml | h | |
| 25 male | 6.5 | 6.69 | 3.42 | 3.32 ± 1.13 | 0.5 |
| 50 female | 14.3 | 14.5 | 1.1 | 8.30 ± 1.025 | 0.25 |
| 100 male | 45.8 | 48.3 | 1.81 | 22.0 ± 0.85 | 0.5 |
| 100 female | 35.9 | 37.3 | 1.89 | 17.3 ± 0.85 | 0.5 |