Table 2

Effect of ketoconazole on EEG pharmacodynamics of midazolam

ControlWith Ketoconazole
IntravenousIntragastricIntravenousIntragastric
E max (% in excess of 100%)86  (±10)79  (±13)
EC50(ng/ml)69.9 (±17.4)2-150 54.6 (±15.3)2-160 142.4 (±38.4)2-150 93.7 (±25.0)2-160
Exponent1.43 (±0.22)1.55 (±0.55)1.37 (±0.33)1.18 (±0.18)
t 1/2KEO(min)7.2 (±3.5)8.0 (±1.4)7.2 (±3.5)13.5 (±5.2)

Values are mean (±S.E.), n = 4.

  • ↵2-150  p < 0.01.

  • ↵2-160  p < 0.08, outcome of comparison of control versus ketoconazole conditions based on t test on ranks.