In vivo pharmacokinetics of midazolam in rats
| Intravenous (5 mg/kg) | Intragastric (15 mg/kg) | |||
|---|---|---|---|---|
| Control | With Ketoconazole | Control | With Ketoconazole | |
| C max(ng/ml) | 114 (±13)1-150 | 698 (±11)1-150 | ||
| Elimination half-life (h) | 0.49 (±0.05) | 0.61 (±0.02) | 1.03 (±0.15) | 0.98 (±0.10) |
| Total AUC (ng/ml × h) | 1051 (±14)1-150 | 1528 (±22)1-150 | 237 (±28)1-150 | 1534 (±26)1-150 |
| Volume of distribution (l/kg) | 3.1 (±0.6) | 2.7 (±0.2) | ||
| Clearance (ml/min/kg) | 79 (±2)1-150 | 55 (±2)1-150 | 1054 (±97)1-150 | 163 (±4)1-150 |
| NetF | 0.11 (±0.4)1-150 | 0.36 (±0.06)1-150 | ||
Values represent the mean (±S.E.), n = 4. Because of an outlying value in one animal in the intragastric control condition, values of Cmax, AUC, and clearance were subjected to logarithmic transformation for purposes of averaging.
↵1-150 Indicates significant difference (p< 0.05) between control and ketoconazole conditions based on pairedt test on ranks.