EMD 68843 prevents the serotonin syndrome induced by 8-OH-DPAT
| Treatment (mg/kg) | Posture | Hind Limb Abduction | Head Weaving | Tremor | Forepaw Treading | Straub Tail | 5-HT Syndrome (%) |
|---|---|---|---|---|---|---|---|
| DPAT (1.0) | 2.2 | 2.3 | 2.0 | 1.7 | 2.3 | 2.3 | 100 |
| EMD (3.0) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 |
| EMD (3.0)/DPAT (1.0) | 0.9 | 1.2 | 0.3 | 0.5 | 0.3 | 0.3 | 0 |
| EMD (1.0)/DPAT (1.0) | 1.5 | 1.5 | 0.8 | 0.3 | 1.0 | 1.0 | 33 |
| EMD (0.3)/DPAT (1.0) | 1.9 | 2 | 1.7 | 1.8 | 2.0 | 2.0 | 88 |
Rats were observed for 15 min after drug administration and scored for the intensity, appearance, and degree of expression of the six behavioral components of the serotonin syndrome on a 0 to 3 scale. Values shown are mean intensity scores on 0 to 3 scale for each symptom. Rats that displayed a score of 2 or higher on four or more signs were considered to display the serotonin syndrome (n = 6 rats for each group).