Table 1

Six treatment groups (A–F) with their corresponding administered amount of alphaxalone, infusion time, number of animals, vehicle, averaged body weight, and dose normalized for body weight (mean ± S.E.M.)

GroupAmountInfusion TimenVehicleBody WeightDose
mg min kg mg · kg−1
A0.5058DMSO0.312  ± 0.0111.62  ± 0.06
B1.25157DMSO0.342  ± 0.0071-a 3.67  ± 0.07
C1.2558DMSO0.263  ± 0.0121-b 4.83  ± 0.21
D2.5057DMSO0.349  ± 0.0131-a 7.21  ± 0.23
E2.5057DMSO0.264  ± 0.0099.54  ± 0.84
F2.5057HPβCD0.280  ± 0.0109.02  ± 0.96

Vehicle was either 100 μl of DMSO or 100 μl of 25% (w/v) HPβCD.

  • 1-a  Significantly higher than E and F.

  • 1-b  Significantly lower than A, B, and D.