Plasma prolactin levels (nanograms per milliliter; mean ± S.E.M.) measured 1 h after s.c. injection of solvent or the indicated doses of the compounds
| Test Compound | Dose | Ntested | Prolactin1-a | N>20 ng/ml/Ntested |
|---|---|---|---|---|
| mg/kg, s.c. | ng/ml; mean ± S.E.M. | |||
| Solvent | 0 | 771-b | 3.5 ± 0.7 | 4 /77 |
| Amisulpride | 0.00063 | 5 | 12 ± 3 | 1 /5 |
| 0.0025 | 5 | 22 ± 7 | 3 /5 | |
| 0.01 | 5 | 115 ± 49 | 5 /5 | |
| 0.04 | 3 | 505 ± 177 | 3 /3 | |
| 0.63 | 3 | 464 ± 55 | 3 /3 | |
| 2.5 | 3 | 464 ± 48 | 3 /3 | |
| 10.0 | 3 | 504 ± 142 | 3 /3 | |
| Risperidone | 0.0025 | 5 | 6.6 ± 3.2 | 0 /5 |
| 0.01 | 5 | 50 ± 7 | 5 /5 | |
| 0.04 | 5 | 469 ± 149 | 5 /5 | |
| 0.16 | 5 | 560 ± 132 | 5 /5 | |
| Olanzapine | 0.04 | 5 | 2.9 ± 1.2 | 0 /5 |
| 0.16 | 5 | 76 ± 32 | 4 /5 | |
| 0.63 | 5 | 118 ± 29 | 5 /5 | |
| 2.5 | 5 | 388 ± 103 | 5 /5 | |
| Quetiapine | 0.16 | 5 | 11 ± 3 | 0 /5 |
| 0.63 | 5 | 28 ± 14 | 3 /5 | |
| 2.5 | 5 | 130 ± 21 | 5 /5 | |
| 10.0 | 5 | 410 ± 109 | 5 /5 |
The last column lists the fraction of rats displaying prolactin levels > 20 ng/ml (adopted as all-or-none criterion for significant prolactin release).