Condition | PAP | PAR | AoP | AoR | HR | CI | LVdP/dt |
---|---|---|---|---|---|---|---|
Control | |||||||
Normoxia (n = 4) | 11 ± 1 | 62 ± 9 | 89 ± 3 | 504 ± 36 | 162 ± 11 | 179 ± 22 | 2829 ± 393 |
Hypoxia (n = 4) | 21 ± 21-160 | 127 ± 131-150 | 86 ± 3 | 568 ± 27 | 195 ± 71-150 | 149 ± 8 | 3487 ± 532 |
PD 156707 treatment | |||||||
Normoxia (n = 7) | 15 ± 0.5 | 78 ± 8 | 90 ± 4 | 679 ± 96 | 182 ± 20 | 145 ± 14 | 4921 ± 42 |
Hypoxia (n = 6) | 15 ± 0.71-151 | 64 ± 101-164 | 72 ± 5 | 368 ± 71 | 217 ± 11 | 238 ± 35 | 4410 ± 271 |
PD 180988 treatment | |||||||
Normoxia (n = 3) | 12 ± 0.7 | 46 ± 2 | 90 ± 5 | 331 ± 17 | 200 ± 5 | 268 ± 3 | 4688 ± 1000 |
Hypoxia (n = 5) | 15 ± 11-151 | 110 ± 17 | 92 ± 3 | 673 ± 62 | 214 ± 10 | 140 ± 12 | 4448 ± 578 |
Hypoxia/low dose treatment (n = 4) | 14 ± 21-151 | 58 ± 141-151 | 86 ± 5 | 332 ± 331-151 | 224 ± 13 | 254 ± 31 | 5930 ± 1861 |
Control values for normoxia and hypoxia were obtained in sequence in the same experiment and results with PD 180988 treatment apply to the high dose, unless otherwise specified. Note that differences due to treatment were accepted as significant only after this significance had been validated by comparing these values with their own baseline values before treatment (not shown). Hence, any other apparent difference in treatment groups versus controls not satisfying this criterion could be ascribed to a change in baseline rather than an ETAR antagonist effect. Values are means ± S.E.M. at 60 min from the start of the recording (for details, see text).
n, number of experiments; PAP, pulmonary artery pressure (mm Hg); PAR, pulmonary artery resistance (mm Hg per milliliter per minute per kilogram); AoP, aortic pressure (mm Hg); AoR, aortic resistance (mm Hg per milliliter per minute per kilogram); HR, heart rate (beats per minute); CI, cardiac index (milliliters per kilogram); LVdP/dt, left ventricular dP/dt (mm Hg per second).
↵1-150 p < 0.05,
↵1-160 p< 0.01 versus normoxia in the control group;
↵1-151 p < 0.05,
↵1-164 p < 0.01 versus untreated animal under the same condition of oxygenation.