Table 1

Digoxin pharmacokinetic parameters after oral administration (33.3 μg/kg)

AUCCL/FMRTVd/Ft1/2β
mg min l−1 10−3 l min−1kg−1 min l kg−1 min
Controls3.5  ± 0.59.6  ± 0.53.4  ± 0.3202  ± 17168  ± 15
rIL29.7  ± 1.51-160 3.8  ± 0.51-165 4.7  ± 0.31-150 283  ± 191-160 218  ± 91-150

Data are expressed as mean ± S.E.M. (n = 6).

  • t1/2β, elimination half-life.

  • */**/*** Significantly different from controls (

  • 1-150p < 0.05,

  • 1-160p < 0.01,

  • 1-165p < 0.001).