ISIS-3082 | ISIS-9388 | ISIS-9389 | |
---|---|---|---|
Half-life (min)2-a 2-b | 23.3 ± 3.8 | 49.0 ± 2.2 | 23.6 ± 0.3 |
Distribution volume (ml/kg)2-a 2-b | 63.9 ± 9.3 | 52.6 ± 4.4 | 59.8 ± 9.9 |
Total plasma clearance (ml/min/kg)2-a 2-b | 1.95 ± 0.25 | 0.74 ± 0.03 | 1.75 ± 0.28 |
↵2-a Rats were intravenously injected with [3H]ISIS-3082, [3H]ISIS-9388, or [3H]ISIS-9389, all at a dose of 1 mg/kg of body weight. The clearance of radioactivity from the blood plasma was followed for 90 to 180 min, and pharmacokinetic parameters were calculated as indicated under Materials and Methods.
↵2-b Values are means ± S.E.M. of three to four rats.