Drug Kd estimates fromkoff/kon
| Subtype | SEP-174559 | (R,S)-ZOP |
|---|---|---|
| α1β2γ2 | 1.8 ± 0.4 (9) | 0.2 ± 0.1 (9) |
| α2β2γ2 | 3.3 ± 0.3 (5) | 0.6 ± 0.1 (5) |
| α3β2γ2 | 5.4 ± 0.6 (3) | 1.4 ± 0.2 (4) |
Values are mean ± S.E.M. in micromolar for (n) observations. GABA concentration was 10 μM. Drug concentrations were 20 μM.
ZOP, zopiclone.