ED50 values for generalization to the discriminative stimulus effects of i.c.v. isoproterenol in rats and for antagonism of 6-hydroxydopamine-induced depletion of heart norepinephrine in mice
| Drug | Generalization to Isoproterenol Discrimination1-a | Antagonism of 6-Hydroxydopamine1-b |
|---|---|---|
| Bupropion | 0.003 | |
| Protriptyline | 0.01 | 0.12 |
| Phenelzine | 0.03 | |
| Venlafaxine | 0.07 | |
| Desipramine | 0.32 | 0.25 |
| Mirtazapine | 0.44 | |
| Nisoxetine | 1.69 | 0.90 |
↵1-a ED50 values for generalization to the discriminative stimulus effects of i.c.v. isoproterenol in rats, as calculated by nonlinear regression analysis (Draper and Smith, 1966; O'Donnell, 1990).
↵1-b ED50 values for inhibition of 6-hydroxydopamine-induced depletion of heart norepinephrine in mice in vivo (Fuller, 1981).