Pharmacokinetic variables for recirculatory ICG, antipyrine, and thiopental kinetic models (N = 5)
| Marker/Drug | Volumes2-a | Clearances2-b | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VC | VT-P | VND-F | VND-S | VT-F | VT-S | VSS | CLND-F | CLND-S | CLT-F | CLT-S | CLE | ΣCL | |
| liters | l/min | ||||||||||||
| ICG | 0.92 | 0.17 | 1.74 | 2.83 | 1.02 | 1.65 | 0.33 | 3.00 | |||||
| (0.25) | (0.07) | (0.50) | (0.75) | (0.35) | (0.61) | (0.08) | (0.89) | ||||||
| Antipyrine | 1.07 | 0.15 | 0.67 | 7.11 | 24.15 | 33.00 | 1.09 | 1.12 | 0.66 | 0.13 | 3.00 | ||
| (0.28) | (0.03) | (0.38) | (4.29) | (4.97) | (6.62) | (0.47) | (0.43) | (0.15) | (0.05) | (0.89) | |||
| Thiopental | 1.11 | 0.19 | 0.70 | 14.26 | 37.05 | 53.12 | 1.18 | 1.29 | 0.36 | 0.17 | 3.00 | ||
| (0.28) | (0.03) | (0.34) | (7.42) | (10.76) | (14.40) | (0.47) | (0.49) | (0.12) | (0.04) | (0.89) | |||
Values are mean (±S.D.).
↵2-a Shown are the volumes (V) of the two parallel central (C) circuits, including the pulmonary tissue (T-P), the rapidly equilibrating (fast) nondistributive (ND-F) and slowly equilibrating (slow) nondistributive (ND-S) intravascular circuits and the nondistributive peripheral pathway (ND), and the rapidly equilibrating (fast) (T-F) and slowly equilibrating (slow) (T-S) tissues. The volume of distribution at steady state (VSS) equals the sum of all volumes except the antipyrine and the thiopental pulmonary volumes, which are represented in their VC values because antipyrine and thiopental VT-P are equal to the difference between the antipyrine and thiopental VC values and the VC described by ICG, respectively.
↵2-b Shown are the clearances (CL) of the rapidly equilibrating (fast) nondistributive (ND-F) and slowly equilibrating (slow) nondistributive (ND-S) intravascular circuits and the nondistributive peripheral pathway (ND), the rapidly equilibrating (fast) (T-F) and slowly equilibrating (slow) (T-S) tissues, elimination clearance (CLE), and the sum of all clearances (ΣCL), which equals the ICG (dye dilution) cardiac output determined at the moment of marker injection.