Mean ± S.D. pharmacokinetic parameters of RESAGL and RESGLU following oral administration of 50 mg/kg to bile-donor rats (n = 3) rats with their bile cannula connected into the duodenum of bile-recipient rats (n = 3)
| Bile-Donor Rats | Bile-Recipient Rats | |||
|---|---|---|---|---|
| RESAGL | RESGLU | RESAGL | RESGLU | |
| Ae0–12 (μmol) | 0.011 ± 0.003 | 0.010 ± 0.034 | 0.082 ± 0.039 | 0.158 ± 0.087 |
| AUC0– t (μmol·h/l) | 1.70 ± 0.39 | 106.8 ± 25.2 | 0.65 ± 0.57 | 32.4 ± 8.3 |
| AUCinf (μmol·h/l) | 1.80 ± 0.39 | 108.7 ± 26.9 | N.A. | N.A. |
| C max (μmol/l) | 3.5 ± 0.8 | 48.8 ± 20.1 | 2.9 ± 0.3 | 9.1 ± 2.1 |
| % ER | N.A. | N.A. | 24.7 ± 15.1 | 24.0 ± 8.5 |
| T max (h) | 0.25 ± 0.00 | 0.67 ± 0.29 | 6.0 ± 0.0 | 6.0 ± 0.0 |
| T 1/2 (h) | 0.33 ± 0.05 | 1.79 ± 0.61 | N.A. | N.A. |
N.A., not applicable.