Table 3

Summary of test results in rats trained to discriminate CP 55,940 (0.03 mg/kg, i.p.) from vehicle

Compound	Application	Type of test	% Drug Lever Selections ED₅₀	95% CL
			mg/kg	mg/kg
BAY 38-7271	i.p.	Generalization	0.015	0.010–0.023
BAY 38-7271	i.v.	Generalization	0.0004	0.0001–0.0011
CP 55,940	i.p.	Generalization	0.009	0.005–0.016
HU-210	i.p.	Generalization	0.004	0.002–0.010
WIN 55,212-2	i.p.	Generalization	0.24	0.10–0.55
Δ⁹-THC	i.p.	Generalization	0.58	0.28–1.23
SR 141716A ⁺ vehicle	i.p.	Generalization	>10
SR 141716A ⁺ CP 55,940 (0.03)	i.p.	Antagonism	0.65	0.35–1.20
SR 141716A ⁺ BAY 38-7271 (0.03)	i.p.	Antagonism	1.14	0.49–2.68

Generalization tests were performed 30 min after application of the test compound (except for HU-210, where the injection-test interval was 120 min). In the antagonism study, pretreatment with SR 141716A (or vehicle; i.p.) occured 10 min before treatment with CP 55,940 or BAY 38-7271 (0.03 mg/kg or vehicle, i.p.; n = 6–16 rats, randomly allocated to each test condition).

CL, confidence limits.