Table 1

B_max and K_d values of BAY 38-7271 and CP 55,940 at rat brain membranes, human cortex membranes, human recombinant CB1, and human recombinant CB2 receptors (radioligand [³H]BAY 38-7271)

Compound	Rat Brain Membranes		Human Cortex Membranes		Recombinant Human CB1 Receptor		Recombinant Human CB2 Receptor
Compound	B_max	K_d	B_max	K_d	B_max	K_d	B_max	K_d
	pM/mg	nM	pM/mg	nM	pM/mg	nM	pM/mg	nM
BAY 38-7271	3.01 ± 0.46	1.84 ± 1.44	0.23^1-a	2.10^1-a	0.87 ± 0.13	2.91 ± 0.30	1.88 ± 0.21	4.24 ± 0.18
CP 55,940	3.32 ± 0.32	2.37 ± 1.49	0.18^1-a	1.29^1-a	0.47 ± 0.18	1.10 ± 0.39	1.75 ± 0.17	4.20 ± 0.28

↵1-a Values from one preliminary experiment; all other values are the mean and standard deviation of at least three independent experiments, each performed in triplicate.