Table 1

FAA and MAG hydrolytic activities in FAAH(+/+) and (−/−) mice (nanomoles of FAA/MAG per minute per milligram of protein)

BrainLiver
FAAH(+/+)FAAH(−/−)FAAH(+/+)FAAH(−/−)
Anandamide1-a 0.33  ± 0.040.003  ± 0.0021-165 0.53  ± 0.060.01  ± 0.011-165
Oleamide1-a 0.24  ± 0.030.004  ± 0.0021-165 0.54  ± 0.010.03  ± 0.011-165
OEA0.06  ± 0.010.001  ± 0.0011-165 0.11  ± 0.010.002  ± 0.0011-165
PEA0.033  ± 0.0020.002  ± 0.0011-165 0.098  ± 0.0120.002  ± 0.0011-165
2-OG19.7  ± 1.1220.3  ± 2.033.8  ± 2.834.8  ± 2.9

Values represent means ± S.E. n = 6/group (seeMaterials and Methods for details).

  • 1-a  From Cravatt et al. (2001).

  • 1-165  Significantly different from FAAH(+/+) mice (t test, p < 0.001).