Renal histopathology of F-344 Rats Treated With PTH for 1 Year
| Histologic Observations of Progressive Glomerulonephritis | Males | Females | ||
|---|---|---|---|---|
| Intact | PTH40 | Sham | PTH40 | |
| Minimal | 0 | 0 | 8 | 19 |
| Slight | 8 | 4 | 1 | 0 |
| Moderate | 12 | 15 | 1 | 0 |
Severity grades were assigned by the primary pathologist and were confirmed by the peer review pathologist. The incidence and severity for all groups was within that expected for F-344 rats.