Table 5

Biomechanical parameters for ovariectomized F-344 rats treated with PTH for 1 Year

Parameter	ShamB	Sham	Ovx	PTH8	PTH40
Femoral Midshaft
F _u(N)	121 ± 3	127 ± 2	121 ± 2	180 ± 3^b ^s ^o	222 ± 5^b ^s ^o
S(N/mm)	342 ± 7	435 ± 10^b	402 ± 6^b ^s	618 ± 13^b ^s ^o	783 ± 12^b ^s ^o
U(mJ)	45 ± 3	32 ± 1^b	35 ± 2^b	44 ± 3^s ^o	39 ± 2^s
d _u(mm)	0.58 ± 0.02	0.41 ± 0.01^b	0.46 ± 0.02^b ^s	0.41 ± 0.02^b ^o	0.32 ± 0.01^b ^s ^o
Femoral Neck
F _u(N)	96 ± 3	116 ± 2^b	97 ± 3^s	139 ± 3^b ^s ^o	171 ± 3^b ^s ^o
S(N/mm)	130 ± 10	296 ± 16^b	256 ± 16^b	369 ± 42^b ^s ^o	391 ± 20^b ^s ^o
U(mJ)	41 ± 3	32 ± 2^b	23 ± 1^b ^s	40 ± 3^s ^o	46 ± 3^s ^o
d _u(mm)	0.83 ± 0.05	0.50 ± 0.03^b	0.45 ± 0.02^b	0.53 ± 0.04^b	0.51 ± 0.03^b
Lumbar Vertebra
F _u(N)	265 ± 16	222 ± 11	167 ± 8^b ^s	366 ± 14^b ^s ^o	408 ± 25^b ^s ^o
S(N/mm)	2253 ± 287	1780 ± 118	1485 ± 88^b	2755 ± 168^s ^o	2443 ± 195^s ^o
U(mJ)	27.0 ± 2.1	23.7 ± 2.1	17.6 ± 1.5^b	40.4 ± 3.5^b ^s ^o	55.1 ± 4.3^b ^s ^o
d _u(mm)	0.17 ± 0.02	0.18 ± 0.01	0.17 ± 0.01	0.18 ± 0.01^o	0.23 ± 0.01^b ^s ^o

Parameters analyzed included F_u, stiffness (S), work to failure (U), and ultimate displacement (d_u). Data are mean ± S.E.M. for ovariectomized females treated with 0, 8, or 40 μg/kg PTH for 1 year. Significant differences are indicated with respect to sham baseline control (b), sham control (s), and Ovx control (o) (p< 0.05; Fisher's PLSD).